Process Research

Over the years Syncom has acquired a valuable know-how of process research and scale-up. Whenever the objective is to develop scalable and cost effective routes, the creativity and experience of our chemists in custom synthesis will provide the impetus to adjust and improve existing synthetic routes. Many options are possible, like increasing yields by a change of solvents, reagents or work-up procedures, reducing catalyst loadings, replacing chromatography by scalable crystallizations, telescoping of steps or designing improved synthesis routes in general. If the synthesis is aimed at a chiral compound we will certainly take advantage of our expertise in asymmetric synthesis and chiral resolution.
Numerous routes and procedures upgraded by Syncom have been transferred to our clients or CMOs for further scale up and clinical manufacturing.